Mr. Muraleedharan C. V.
Scientist 'G' (Senior Grade) & Scientist-in-Charge
Phone : 0471 2520 259

Academic Qualifications

M. Tech (Control Systems and Instrumentation); Regional Engineering College, Calicut (currently NITC), INDIA (1987).

B. Tech (Electrical Engineering); Regional Engineering College, Calicut (Currently NITC), INDIA (1983).

Professional Record

Lecturer; Regional Engineering College (currently NITC), Calicut, India; (Mar 1985 - Oct 1985).

Scientist / Engineer; Biomedical Technology Wing, SCTIMST, Trivandrum, India; (Nov 1985 - continuing).

Honors

Certified Laboratory Assessor, National Accreditation Board for Testing and Calibration Laboratories (NABL), Government of India.

Approved signatory for Calibration, National Accreditation Board for Testing and Calibration Laboratories, Government of India.

Awards

VI Mantra 2008 from National Instruments , Bangalore, 2008.

Meritorious Invention Award from National Research and Development Corporation (NRDC), New Delhi, 2007.

ISTE-L&T Award from Indian Society for Technical Education, New Delhi -1997.

FIE Foundation Award from FIE Foundation, Kolhapur, 1995.

Republic Day Award from National Research Development Corporation (NRDC), New Delhi, 1994.

Incentive Award for Technology Development from SCTIMST, 1991.

National Technlogy Award, DIPT, GoI, 2014

Area of Interest

Medical devices, Biomaterials .

Information management .

Quality systems, calibration and metrology .

Collaboration

Babha Atomic Research Centre, Mumbai

National Aeronautical Laboratories, Bangalore

CNRS, Paris, France

Central Electrochemical Research Institute, TN

Current Activities

Product development of coronary stent systems, Deep Brain Stimulator, Implantable Cardioverter Defibrillator.

GLP in medical devices, Reference materials, Calibration.

Medical device retrieval analysis.

Coordinator, Technical Research Centre for Biomedical Devices

Patents

Muraleedharan CV, Sumesh S, Pranha D nair, A bioreactor system incorporating perfusion and hydro-pneumatic stimulation for articular cartilage tissue engineering, Indian Patent Application, 2010.

Mohanan PV, Sidharh B, Muraleedharan CV, An in vitro pyrogen test kit using human blood, Indian Patent Application, 2010.

Muraleedharan CV , Sujesh S, A metallic stent for use as support in blood vessels, Indian Patent Application, Dec 2008.

Sujesh S, Muraleedharan CV, A stent for use in blood vessels, Design Registration Application, Dec 2008.

Roy Joseph, Manju S, Rajeev A, Jayakrishnan A, Muraleedharan CV, Vascular graft sealed with biodegradable hydrogel, Indian Patent Application, Dec 2008.

Roy Joseph, Anumon VD, Muraleedharan CV, Curcumin containing coating compositions for treating coronary restenosis, Indian Patent Application, Jul 2008.

Roy Joseph, Muraleedharan CV, Polyester based implant materials with reduced thrombogenicity and a process for making the same, Indian Patent Application 1972/CHE/2006.

Nagesh DS, Muraleedharan CV, Bhuvaneshwar GS, Venous Reservoir with integral cardiotomy reservoir for blood oxygenator , Indian Patent Application, 203/MAS2000.

Nagesh DS, Muraleedharan CV, Bhuvaneshwar GS, A blood oxygenator, Indian Patent Application, 1153/MAS/1999.

Bhuvaneshwar GS, Muraleedharan CV, Neelakantan Nair OS, A method of producing heart valve, US patent No.5,458,286, 1995.

Bhuvaneshwar GS, Muraleedharan CV, Neelakantan Nair OS, Improvements relating to prosthetic cardiac valve and to the method of manufacturing same, European patent No. 93303377, 1993 .

Bhuvaneshwar GS, Muraleedharan CV, Neelakantan Nair OS, Improvements relating to prosthetic cardiac valve and to the method of manufacturing same, Indian patent no. 180653,1992.

Bhuvaneshwar GS, Muraleedharan CV, An epidural sensor for use in intracranial pressure monitoring system, Indian patent application No.751/MAS/91, 1991.

Muraleedharan CV, Bhuvaneshwar GS, Improved humidifier for air, oxygen or other gases, Indian patent No. 180294, 1992.

Rout D, Bhuvaneshwar GS, Pal SN, Muraleedharan CV, Muralitharan M, A shunt device for draining cerebrospinal fluid, Indian patent No. 180185, 1991.

Membership

Institution of Electrical and Electronic Engineers Inc (IEEE).

Material Research Society of India (MRSI).

System Society of India (SSI).

Society for Polymer Science, India (SPSI).

Society for Biomaterials and Artificial Organs, India (SBAOI).

On-going Projects

Development of Improved Tilting Disc Heart Valve Prosthesis .

Development of Coronary Stent Systems Development of Drug Eluting Intra Uterine Contraceptive Device .

Development of Coated Vascular Grafts .

Development of Bioreactors for Tissue Engineering Applications - 3 projects for liver, cartilage and vascular tissue engineering .

Development of Decellularised Animal Tissue for Cardiovascular Applications .

Development of guidelines for implementation of GLP in medical device segment in India.

Medical device retrieval program

Team

Sujesh S, Engineer F.

Ranjith G, Enginer E.

Sajithlal MK, Engineer E.

Rajeev A, Technical Asst.

manog

Presentations

Invited talks

No. of Publications

Technology Transferred

Coated vasvcular graft

Improved heart valve

Vascular graft

Membrane oxygenatoir

Patient Humidifier

Tilting disc heart Valve

Hydrocephalus Shunt System

Publications

Article

1
Mohanan, PV; Muraleedharan, CV; Bhuvaneshwar, GS; Derangere, F.; Sampeur, Y.; Suryanarayanan, R., Evaluation of maximization sensitization of the saline extract of titanium coated with diamond like carbon material, Toxicology International, 2010, 14; 63, http://www.toxicologyinternational.com/article.asp?issn=0971-6580;year=2007;volume=14;issue=1;spage=63;epage=65;aulast=Mohanan;type=0
2
Joseph, R.; Shelma, R.; Rajeev, A.; Muraleedharan, CV, Characterization of surface modified polyester fabric, Journal of Materials Science: Materials in Medicine, 2009, 20; 153-159, http://www.springerlink.com/content/m577m7253k2w0564/
3
Joseph, Leena; Velayudhan, Arumugham; Charuvila, Muraleedharan V; Vayalappil, Muraleedharan C, Reference biomaterials for biological evaluation., J Mater Sci Mater Med, 2009, 20 Suppl 1; S9-17, http://www.ncbi.nlm.nih.gov/pubmed/18648911
4
Prasad, C Krishna; Muraleedharan, C V; Krishnan, Lissy K, Bio-mimetic composite matrix that promotes endothelial cell growth for modification of biomaterial surface., J Biomed Mater Res A, 2007, 80; 644-54, http://www.ncbi.nlm.nih.gov/pubmed/17051537
5
Anilkumar, TV; Shelma, R.; Joseph, R.; Mohanan, PV; Muraleedharan, CV, Implant pathology of polyvinylidene fluoride coated polyethylene terephthalate fabric in rabbits, Indian Journal of Veterinary Pathology, 2007, 31; 11-16, http://www.indianjournals.com/ijor.aspx?target=ijor:ijvp&volume=31&issue=1&article=002&type=fulltext
6
Muraleedharan, CV; Bhuvaneshwar, GS, Titanium Alloys in implant applications, Metals Materials and Processes, 2006, 18; 441
7
Nair, K.; Muraleedharan, CV; Bhuvaneshwar, GS, Developments in mechanical heart valve prosthesis, Sadhana, 2003, 28; 575-587, http://www.springerlink.com/content/4741263g682j0886/
8
Kumari, T V; Anil Kumar, P R; Muraleedharan, C V; Bhuvaneshwar, G S; Sampeur, Y; Derangere, F; Suryanarayanan, R, In vitro cytocompatibility studies of Diamond Like Carbon coatings on titanium., Biomed Mater Eng, 2002, 12; 329-38, http://www.ncbi.nlm.nih.gov/pubmed/12652027
9
Mohanty, M; Anilkumar, T V; Mohanan, P V; Muraleedharan, C V; Bhuvaneshwar, G S; Derangere, F; Sampeur, Y; Suryanarayanan, R, Long term tissue response to titanium coated with diamond like carbon., Biomol Eng, 2002, 19; 125-8, http://www.ncbi.nlm.nih.gov/pubmed/12202172
10
Krishnan, LK; Varghese, N.; Muraleedharan, CV; Bhuvaneshwar, GS; Derangere, F.; Sampeur, Y.; Suryanarayanan, R., Quantitation of platelet adhesion to Ti and DLC-coated Ti in vitro using 125I-labeled platelets, Biomolecular engineering, 2002, 19; 251-253, http://dx.doi.org/10.1016/S1389-0344(02)00029-1