Dr. Syam K.
Professor
Phone :
0471-2524268

MBBS, Government Medical College, Kottayam, Kerala (Mahatma Gandhi University), 1998

MD, Government Medical College, Thiruvananthapuram, Kerala (University of Kerala), Internal Medicine (General Medicine), 2002

DM, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram, Kerala, Neurology, 2005

December 2018 - Continuing : Professor of Neurology

January 2015 - December 2018: Additional Professor of Neurology, SCTIMST

January 2012 - December 2014: Associate Professor of Neurology, SCTIMST

January 2009 - December 2011: Assistant Professor of Neurology, SCTIMST

August 2008- December 2008: Senior Lecturer in Neurology, Government Medical College, Kozhikode, Kerala, India

February 2008- July 2008: Adhoc Consultant, Department of Neurology, SCTIMST.

January 2006 - January 2008 : Consultant Neurologist, St. Mary's Super-specialty Hospital, Thodupuzha, Kerala

Second Rank in Mahatma Gandhi University for MBBS Examination (1997)

Best outgoing student- for MD (General Medicine), Medical College, Thiruvananthapuram (2002)

Neurology India Award for best research paper of the year 2016

Travel Grant Award to attend the International Congress of Parkinson's disease and Movement Disorders, Nice, France (September 2019)

Movement Disorders

Member - International Parkinson and Movement Disorder Society (MDS)

Life member of Movement Disorder Society of India (MDSI)

Life member - Neurological Society of India (NSI)

Life member - Indian Academy of Neurology (IAN)

Life Member - Kerala Association of Neurologists (KAN)

Life member- Indian Medical association

Principal Investigator of ICMR-funded project - Validation of the Malayalam version of Montreal Cognitive Assessment (MoCA) scale and a prospective evaluation of mild cognitive impairment in Parkinson's disease using the Malayalam version (MoCA-M)

Principal Investigator of DBT-funded project - Quantitative estimation of regional brain iron deposition- a potential biomarker for Parkinson's disease and other neurodegenerative conditions causing atypical Parkinsonism

Principal Investigator of ICMR-funded collaborative (with CUSAT, Kochi) project - Exploring the human gut microbiome, metabolome and alpha synuclein in health and Parkinson's disease (PD) - a window to the gut microbiota-brain axis alterations in PD.

Co-Principal Investigator- Genetic Architecture of Parkinson's Disease in India (Funded by Michael J Fox Foundation, USA)

Co-Principal Investigator - Dementia Science Program- Incidence, prevalence and risk analysis of dementia and basic research thereof (Funded by Department of Biotechnology, GoI)

PI/ Co-PI for non-funded projects on Mild Cognitive Impairment in Early Onset Parkinson's disease; Cognitive outcomes of Deep Brain Stimulation Surgery etc

Evaluation of non-motor symptoms in patients with Parkinson's disease from Kerala using Non-Motor Symptoms Scale (NMSS)

Long-term follow-up of bilateral subthalamic nucleus deep brain stimulation for advanced Parkinson's disease patients

Do baseline clinical and Neuropsychological factors predict the occurrence of dementia on follow-up in patients with Parkinson's disease undergoing Deep Brain Stimulation surgery.

14 years of Professional Experience as a Neurologist, 12 years of Professional experience as a teaching faculty in Neurology and 11 years of experience in the Neurological sub-specialty of Movement Disorders, as in December 2019. 11 years of experience in specialized procedures like Deep Brain Stimulation and Botulinum Toxin Therapy for Movement Disorders

Sleep disturbances in Parkinson's disease

Validation of Malayalam version of Montreal Cognitive Assessment (MoCA) for use in patients with Parkinson's disease

Hearing impairment in Parkinson's disease

Effect of subthalamic nucleus Deep Brain Stimulation Surgery on impulsivity in Parkinson's disease patients

Non-motor fluctuations in patients with Parkinson's disease

Non-conventional stimulation paradigms for refractory symptoms in patients undergoing Deep Brain Stimulation for Parkinson's disease

Non-motor symptoms in patients with different sub-types of Parkinson's disease

Progressive Supranuclear Palsy (PSP) - Application of the new MDS diagnostic criteria and prognosis of PSP sub-types

Comprehensive Care Center for Movement Disorders

International Parkinson and Movement Disorders Congress , Nice, France (September 22-26, 2019) : "Mild Cognitive Impairment in Parkinson's disease in South Indian population "Development of a test battery and assessment of prevalence and characteristics"

The Fourth Asian and Oceanian Parkinson's disease and Movement Disorders Congress (AOPMC 2014), November 28-30, Pattaya, Thailand: "Cross Cultural adaptation of Montreal Cognitive Assessment Scale retains in validity for use in patients with Parkinson's disease"

The Third Asian and Oceanian Parkinson's disease and Movement Disorders Congress (AOPMC 2011) and the 8th International Symposium of Asian and Pacific Parkinson Association, March 25th-27th, 2011, Taipei, Taiwan: "Non-motor Symptoms are ubiquitous in Parkinson's disease and distinct from normal aging: a case-control study using Non-Motor Symptoms Scale"

19th Annual Conference of the Indian Academy of Neurology (IANCON 2011), September 22 -25, 2011, Pune. Title of the paper presented: "Ten years follow up of Subthalamic nucleus DBS for advanced Parkinson's disease"

Annual Conference of the Indian Academy of Neurology, 24th-27th October, 2013, Indore (IANCON 2013). Title of the paper presented: "Bilateral Subthalamic Nucleus Stimulation improves Non-Motor Symptoms in advanced Parkinson's disease"

24th Annual Conference of the Indian Academy of Neurology, 10th - 13th November 2016, Kolkata. (IANCON 2016). Presented a research paper on "Dementia-free survival after bilateral subthalamic stimulation for Parkinson's disease"

2nd Annual Conference of the Movement Disorders Society of India, 6th - 8th January 2017, Bangalore (MDSICON 2017). Presented a research paper on "What predicts an early onset of dementia in non-demented patients undergoing subthalamic stimulation for Parkinson's disease"

Invited faculty in the live workshop and symposium on "Deep Brain Stimulation for Parkinson's disease" conducted by the Department of Neurosciences, Sree Venkateshwara Institute of Medical Sciences (SVIMS), Tirupati (25th - 26th May 2018)

Invited faculty for the Continuing Medical Education Program on Movement Disorders, organized by the Department of Neurosciences, Kasturba Medical College, Manipal, on 24th March, 2018 at Manipal. Delivered a lecture on "Surgery for Movement Disorders- Indications and pre-operative evaluation"

Invited faculty for the 7th Annual Conference of the Neurological Surgeons Society of India, 23rd- 25th February 2018, Lucknow (NSSICON 2018). Delivered a lecture on "Evaluation of patients with Movement Disorders and selection criteria for surgery"

Invited faulty for the Annual Conference of the Kairali Neuroscience Society, 10th - 11th February 2018, Kottayam. Delivered a lecture on "Deep Brain Stimulation for Parkinson's disease- when and in whom"

Invited faculty for the 3rd Annual Conference of the Movement Disorders Society of India, 19th - 21st January 2018, Hyderabad (MDSICON 2018). Delivered a lecture on "Impulse control disorders in Parkinson's disease and impact of Deep Brain Stimulation"

Invited faculty in the Continuing Medical Education program on Functional Neurosurgery for Parkinson's disease and Psychiatric disorders, organized by the Amrita Institute of Medical Sciences, Kochi (January 22, 2017). Delivered a lecture on Intra-operative monitoring and programming of DBS for Parkinson's disease.

Invited faculty in the two-day symposium on "Neural functions of the Ageing Brain" held at the Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram (27th - 28th September, 2016). Delivered a lecture on "Relationship between ageing and Parkinson's disease- where do we stand"

Invited faculty for the Mid-term Meeting of Kerala Association of Neurologists held at Thiruvananthapuram (25th October 2015). Delivered a lecture on Psychogenic Movement Disorders.

Article

1
Popa T, Hubsch C, James P, Richard A, Russo M, Pradeep S, Krishan S, Roze E, Meunier S, Kishore A, Abnormal cerebellar processing of the neck proprioceptive information drives dysfunctions in cervical dystonia. , Sci Rep. (Scientific Reports, Nature Publishing Group) , 2018, 8(1):2263, https://www.ncbi.nlm.nih.gov/pubmed/29396401
2
Joseph PS, Syam Krishnan, Narayanappa G, Nair M., Young onset Parkinsonism in a patient with familial central core disease., Neurol India. , 2017, 65:386-388, https://www.ncbi.nlm.nih.gov/pubmed/28290406
3
Krishnan S, Pisharady KK, Surgical treatment of levodopa-induced dyskinesia in parkinson's disease, Ann Indian Acad Neurol., 2017, 20:199-206, http://www.annalsofian.org/article.asp?issn=0972-2327;year=2017;volume=20;issue=3;spage=199;epage=206;aulast=Krishnan
4
Kishore A, James P, Krishnan S, Yahia-Cherif L, Meunier S, Popa T., Motor cortex plasticity can indicate vulnerability to motor fluctuation and high L-DOPA need in drug-naive Parkinson's disease., Parkinsonism Relat Disord. , 2017, 35:55-62, https://www.ncbi.nlm.nih.gov/pubmed/28003105
5
Rajan, R., Krishnan, S., Kesavapisharady, K. K. and Kishore, A., Malignant Subthalamic Nucleus-Deep Brain Stimulation Withdrawal Syndrome in Parkinson's Disease., Mov Disord Clin Pract,, 2016, 3: 288?291., http://onlinelibrary.wiley.com/doi/10.1002/mdc3.12271/full
6
Krishnamoorthy S, Rajan R, Banerjee M, Kumar H, Sarma G, Krishnan S, Sarma S, Kishore A., Dopamine D3 receptor Ser9Gly variant is associated with impulse control disorders in Parkinson's disease patients., Parkinsonism Relat Disord. , 2016, 30:13-7., https://www.ncbi.nlm.nih.gov/pubmed/27325396
7
Krishnan S, Prasad S, Pisharady KK, Sarma G, Sarma SP, Kishore A, The decade after subthalamic stimulation in advanced Parkinson's disease: A balancing act., Neurol India. , 2016, 64(1):81-9, http://www.ncbi.nlm.nih.gov/pubmed/26754997
8
Krishnan S, Justus S, Meluveettil R, Menon RN, Sarma SP, Kishore A., Validity of Montreal Cognitive Assessment in Non-English speaking patients with Parkinson's disease., Neurol India. , 2015, 63(1):63-7., http://www.ncbi.nlm.nih.gov/pubmed/25751471
9
Syambabu Chandran, Syam Krishnan, Gangadhara Sarma S, Sankara sarma P, Asha Kishore., Gender influence on selection and outcome of deep brain stimulation for Parkinson's disease., Ann Indian Acad Neurol, 2014, 17:66-70., http://www.ncbi.nlm.nih.gov/pubmed/24753663
10
Kishore A, Popa T, Balachandran A, Chandran S, Pradeep S, Backer F, Krishnan S, Meunier S, Cerebellar sensory processing alterations impact motor cortical plasticity in Parkinson's disease: clues from dyskinetic patients., Cereb Cortex., 2014, 24(8):2055-67, http://www.ncbi.nlm.nih.gov/pubmed/23535177