Dr. Rekha M.R.
Scientist 'G'
Phone : 0471-2520284

Ph.D Biochemistry, University of Kerala, 2001.

M.Phil Biochemistry, University of Kerala, 1996.

M.Sc Biochemistry, University of Kerala, 1994.

B.Sc Chemistry, University of Kerala, 1992.

Scientist F (2017 - till date)

Scientist E (2014 - 2017)

Scientist- D (2011- 2014)

Scientist -C (2007-2011, SCTIMST).

Research Associate (2002-2007, SCTIMST).

Research Associate (1996-2001, CTCRI).

Received WBC 2016 - Developing Country Scholarship Award at 10th World Biomaterials Congress held at Montreal, Canada during May 17-22, 2016

Nanomedicine, Nanotechnology based drug and gene delivery systems, oral peptide delivery systems.

Non-viral gene delivery systems, nano polymeric gene and drug delivery systems, drug delivery systems and pH probes for wound dressings

pH sensitive nanoparticle formulation for oral delivery of proteins/peptides, patent granted (EP 1924248 B1 dated 22/10/2014, CA 2621641 dated 21/10/2014) Inventors: Chandra P Sharma and Rekha M.R.

Method for In-Vivo Binding of Chromatin Fragments. PCT filed. US Patent publication no. 20150218262 (06/08/2015). Inventors: Indraneel Mittra, Rekha M.R, C.P. Sharma, G.S. Bhuvaneshwar, Kavita Pal

GATE 1995 - 98.51 percentile

UGC Junior Research Fellowship -1995-1996

MRSI

SBAOI

STERMI

SPSI

ISRC

Oral Insulin Delivery System ( 2017 to 2020)

Chitosan based antioxidant wound dressing for controlled antibiotic delivery (2017 to 2019)

Indo-Spanish (under DST) project - "Development of nanodevices for DNA delivery and cell transfection using Elastin Like Polymers (ELPs) coupled to cell interaction motifs" (Co-PI) (October 2010 to Septmber 2013)

DBT project - Nonviral gene delivery vectors for therapeutic gene and siRNA delivery for glioma targeting: In vitro evaluation of cationized pullulan based materials. (April 2012 to August 2015)

6 Book Chapters

66 publications in International Peer Reviewed Journals

Synthesis and evaluation of multifunctional nanothiomatrices for an efficient antitumour therapy, done by Ms. Priya S.S

Non-viral gene delivery in cancer cells using polysaccharides modified with polyethyleneimine and vinyl monomers, done by Ms. Caroline Diana Sherly

POLYETHYLENEIMINE BASED NON-VIRAL VECTORS FOR p53 GENE DELIVERY IN CANCER CELLS, done by Linsha Mali A.

FORMULATION AND EVALUATION OF MUCOADHESIVE CHITOSAN MICROPARTICLES FOR ORAL INSULIN DELIVERY: AN IN-VITRO STUDY, done by Hanna Karneena Poulose

PHYSICO CHEMICAL CHARACTERIZATION OF CHITOSAN BASED SCAFFOLD AS WOUND HEALING BIOMATERIAL, done by Divya M.R.

Caroline D.S. and Rekha M.R. Exploring the efficacy of ethylene glycol dimethacrylate crosslinked cationised pullulan for gene delivery in cancer cell. Journal of Drug Delivery Science and Technology, 68, 2022, 2022, 103067, https://doi.org/10.1016/j.jddst.2021.103067 (IF: 5.062)

G P Rajalekshmy, M R Rekha, Wound healing effects of glucose oxidase ? peroxidase incorporated alginate diamine PEG-g-poly (PEGMA) xerogels under high glucose conditions: An in vitro evaluation. Materialia, 23, 2022, 101464, https://doi.org/10.1016/j.mtla.2022.101464. (Cite score 4.7)

Priya S.S. and Rekha M.R. Intracellular delivery of p53 gene and drug using cationised pullulan thiomer lowers the effective therapeutic doses of chemotherapeutic drug in cancer cells. Materials Today Communications. https://doi.org/10.1016/j.mtcomm.2022.103129 (IF: 3.662)

Linsha Mali, A., Priya, S. S., Rekha, M. R., Hydrophobic and hydrophilic modifications of polyethylenimine towards gene delivery applications. Journal of Applied Polymer Science, 2021, 138( 45), e51323. https://doi.org/10.1002/app.51323 (IF: 3.057)

GP Rajalekshmy, MR Rekha. Synthesis and evaluation of an alginate-methacrylate xerogel for insulin delivery towards wound healing applications. Therapeutic Delivery, 12, 2021, 215-234. https://doi.org/10.4155/tde-2020-0128 (IF: 2.448)

Rajalekshmy GP, Rekha MR, Strontium ion cross-linked alginate-g-poly (PEGMA) xerogels for wound healing applications: in vitro studies, Carbohydrate Polymers, 251, 2021, 117119 (IF: 10.723)

Caroline Diana Sherly, Rekha M.R and Harikrishnan V.S. Cationised dextran and pullulan modified with diethyl aminoethyl methacrylate for gene delivery in cancer cell Carbohydrate Polymers, 242, 2020, 116426 (IF: 9.381)

Dhanya G.R., Caroline Diana Sherly and Rekha M.R. Histidine and arginine conjugated starch-PEI and its corresponding gold nanoparticles for gene delivery. International Journal of Biological Macromolecules, 120, 2018, 999-1008. (IF: 4.787)

Priya S.S and Rekha M.R. Redox sensitive cationic pullulan for efficient gene transfection and drug retention in C6 glioma cells. International Journal of Pharmaceutics, 530, 2017, 401-414. (IF:3.862)

Caroline DS and Rekha M.R. Efficacy of vinyl imidazole grafted cationized pullulan and dextran as gene delivery vectors: A comparative study. International Journal of Biological Macromolecules, 105, 2017, 947-955. (IF:3.909)

Reviewer for International Journals in the field of Biomaterial Science and Drug/gene delivery, Wound healing

Article

1
Rekha MR and Sharma C.P., Simultaneous effect of thiolation and carboxylation of chitosan particles towards mucoadhesive oral insulin delivery applications: an in vitro and in vivo evaluation, Journal of Biomedical Nanotechnology, 2015, 11, 165-176, http://www.ingentaconnect.com/content/asp/jbn/2015/00000011/00000001/art00014
2
Lizebona A.A and Rekha M.R, Betaine conjugated cationic pullulan as effective gene carrier., International Journal of Biological Macromolecules, 2015, 72, 819-826, http://www.sciencedirect.com/science/article/pii/S014181301400645X
3
Maria J. Pi?a, Susan M. Alex, Francisco J. Arias, Mercedes Santos, Jose C. Rodriguez-Cabello, Rekha M.R. and Chandra P. Sharma, Elastin-like recombinamers with acquired functionalities for gene-delivery applications, Journal of Biomedical Materials Research Part A, 2015, 103, 3166-3178, http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.35455/full
4
Soma Dey, Lizebona August Ambattu, PR Hari, MR Rekha, K Sreenivasan, Glutathione-bearing fluorescent polymer-curcumin conjugate enables simultaneous drug delivery and label-free cellular imaging, Polymer, 2015, 75, 25-33, http://www.sciencedirect.com/science/article/pii/S0032386115301592
5
Lizebona A.A and Rekha M.R, Collagen synthesis promoting Pullulan-PEI-Ascorbic acid conjugate as an efficient anti-cancer gene delivery vector, Carbohydrate Polymers, 2015, 126, 52-61, http://www.sciencedirect.com/science/article/pii/S014486171500226X
6
Rekha M.R and Sharma C.P., Recent advances in the oral delivery of insulin, Recent Patents on Drug Delivery & Formulation, 2014, 8, 155-159, http://www.ingentaconnect.com/content/ben/ddf/2014/00000008/00000002/art00007
7
Priya S.S, Rekha M.R and Sharma C.P, Pullulan-protamine as efficient haemocompatible gene delivery vector: Synthesis and in vitro characterization, Carbohydrate Polymers, 2014, 102, 207-215, http://www.sciencedirect.com/science/article/pii/S0144861713011648
8
Mitha Ann Thampy and Rekha M.R, Multifunctional polymeric nanoplexes for anticancer co-delivery of p53 and Mitoxantrone, Journal of Materials Chemistry B, 2014, 2, 8005-8014, http://pubs.rsc.org/en/content/articlehtml/2014/tb/c4tb01298d
9
M.R. Rekha and Sharma C.P, Oral delivery of therapeutic protein/peptide for diabetes-Future perspectives., International Journal of Pharmaceutics, 2013, 440, 48-62, http://www.sciencedirect.com/science/article/pii/S0378517312003249
10
Thasneem Y.M., Rekha M.R., Sajeesh S., and Sharma C.P, Biomimetic mucin modified PLGA nanoparticles for enhanced blood compatibility., Journal of Colloid and Interface Science, 2013, 409, 237-244, http://www.sciencedirect.com/science/article/pii/S0021979713006449