Dr. Manju S.
Scientist 'E'
Phone : 9539263017

PhD, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India, 2012

Master of Science in Chemistry (Polymer Sciences), Mahatma Gandhi University, Kottayam, Kerala, India, 2004

Bachelor of Science in Chemistry, Kerala University, Thiruvananthapuram, Kerala, India, 2002

Scientist E, SCTIMST (January 2022-Till Date);

Scientist D, SCTIMST (Dec 2018- Dec 2021)

Adjunct Assistant Professor of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America. October 2017-November 2018

Research Associate, Dept. Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America. July 2017-November 2018

Har Gobind Khorana-Innovative Young Biotechnologist Award , Department of Biotechnology, Govt. of India (IYBA 2020)

Certificate of outstanding contribution in Reviewing , Carbohydrate Polymers (Elsevier 2018)

ESB Rudolf Cimdins Scholarships, European Society for Biomaterials (ESB), Lausanne, Switzerland, 2009

Travel Award, Department of Biotechnology, New Delhi, India, 2009

Polymers, Injectable hydrogels, Guided bone tissue regeneration, Dental materials

Drug Delivery, nanotechnology, Mucoadhesive polymers

Antimicrobial resistance and Ionic liquids/Polyionic liquids- Synthesis and Evaluations

Plasticizer free polymer network for biomedical applications & Molecular imprinted polymers for biosensing

Manju Saraswathy, Anusree, ?Plasticizer free Acrylic Denture Softliners?. Indian Patent Application # 202241019852, filed on 1 April 2022

Manju Saraswathy, Rekha M.R.; Drug Eluting Mucoadhesive Bandage; Indian patent application # 202341056012, Filed on 21 August 2023

Manju Saraswathy, Sreejith S.L., Suresh Babu. ?Nanogel Modified Glass Ionomer Cement?. Indian Patent Application # 202341003519, filed on 18 January 2023

Manju, Saraswathy; Paila Ravisankar; Sreejith SL; A Saliva Absorption Pad Indian Patent App. 202141051940 filed on 12th November 2021

Manju, Saraswathy; Manoj, Komath; A P, Hrishi; A, Kishore; A system for the spillage control and fluid waste management in hospitals Indian Patent App. 202041019872 filed on 11 May 2020 Manju Saraswathy and Manoj, Komath. ?Disposable disinfectant absorbent sponge? Indian Patent App. 202041015399 filed on 08 April 2020

Nair, Devatha P; Simberg,Dimitri; M. Saraswathy, Targeted Nanogel for Urinary Bladder Therapies, PCT/US2018/024049. (International Publication Number: WO/2018/175899)

Nair, Devatha P; Kahook, Malik Y; Stansbury, Jeffrey; Torbati, Amir; Marks, Zefram; M, Saraswathy, Nanogels for Ophthalmic Applications, PCT/US16/025319. (International Publication Number: WO 2016/ 161144 A1)

Nair, Devatha P; Kahook, Malik Y; Torbati, Amir; M, Saraswathy, Copolymer Formulation for Lenses, PCT/US2016/013675. (International Publication Number: WO 2016/ 115507 A1)

Postdoctoral Fellow, Dept. Craniofacial Biology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, July 2015-June 2017

Postdoctoral Research Associate, Dept. Pharmaceutical Sciences, South Dakota State University, Brookings, South Dakota, January 2014-June 2015

Postdoctoral Research Associate, Dept. Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, July 2012-2013

Material Research Society of India (MRSI)

The Society of Polymer Science India (SPSI)

Asian Polymer Association (APA)

Society for Biomaterials and Artificial Organs (India)

Indian Society for Dental Research(ISDR)

Development of drug eluting mucoadhesive bandages for the treatment of localized oral disease conditions: in vitro and in vivo evaluations (Role: PI); Technical Research Centre, SCTIMST (2023-2024)

In situ formation of injectable thermoreversible silk protein hydrogel for Guided-Bone Tissue Engineering (Role: Co-PI) Funding agency: ICMR (2023-2026)

Development of plasticizer free acrylic denture soft liners using nanogel additives (Role: P.I) Funding agency: IYBA, DBT (2021-2024)

Mucoadhesive Bandages for Oral Drug Delivery Applications (Role: P.I.); Technology development fund, SCTIMST (2020-2023) Chitra AcryloSorb Respiratory Secretion Solidification System (Role: P.I.); Technical Research Centre, SCTIMST (2020)

Development of modified Glass Ionomer Cement to Improve Mechanical Properties (Role: P.I.) Funding: SRG, SERB; Dec 2020-March 2023

Adjunct Assistant Professor of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, October 2017-November 2018

Research Associate, Dept. Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, July 2017-November 2018

Postdoctoral Fellow, Dept. Craniofacial Biology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, July 2015-June 2017

Postdoctoral Research Associate, Dept. Pharmaceutical Sciences, South Dakota State University, Brookings, South Dakota, January 2014-June 2015

Postdoctoral Research Associate, Dept. Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, July 2012-2013

10th Training Programme on Science and Technology for Rural Societies for Women Scientist & Technologist conducted during February 21-25, 2022 organized by Indian Institute of Public administration, New Delhi, sponsored by Department of Science and Technology, Govt. India

11th Training Programme on Science and Technology and Emerging Trends in Governance conducted during December 20-24, 2021 organized by Indian Institute of Public administration, New Delhi,sponsored by Department of Science and Technology, Govt. India

Peer-reviewed scientific articles # 27 ; Total impact factor: 152 ; Google scholar citations: 1626; h index: 17; US Patent Applications # 3; Indian Patent application (filed) # 6, Book Chapters # 3

(1) Development of Mucoadhesive Bandages for Oral Drug Delivery Applications (Ms. Ankita Modi 2023) (2) SUPERABSORBENT POLYMERS FOR THE SAFE DISPOSAL OF BODY FLUIDS IN HOSPITALS (Mr. Paila Ravi Sankar 2021)

1. Manju Saraswathy, Komath, M., Ragini, D. D., SomanPillai SarojiniAmma, P., Lathikumari, S. S., & Akhandanandan, M. N. Bactericidal Activity of Superabsorbent Polymer Granules for Their Applications in Respiratory Fluid Solidification Systems. ACS omega (2023), 8(28), 25114-25121 [impact factor: 4.1] 2. Sankar, P. R., Lathikumari, S. S., Manju Saraswathy, Superabsorbent Polymer Sponge for Saliva Absorption Pad. Journal of Advanced Oral Research, (2023) 14(1), 36-43. 3. S.L. Sreejith, Manju Saraswathy; Ionic Liquids and Its Antimicrobial Activities; Research in Medical & Engineering Sciences 2022; 10 (2); 1061-1065 4. S.L. Sreejith, Manju Saraswathy; Chemistry of Dental Materials; Swadeshi Vigyan Patrika 2022; 3 (1) 32-36

3. K. Borgmann J.Proulx, C. Joshi, S. Vijayaraghavalu, Manju Saraswathy, V. Labhasetwar, A. Ghorpade, Arginine-Modified Polymers Facilitate Poly (Lactide-Co-Glycolide)-Based Nanoparticle Gene Delivery to Primary Human Astrocytes, International Journal of Nanomedicine (2020), Vol.15, pp. 3639-3647 [impact factor: 4.471]

4. C. R. Joshi, V. Raghavan, S. Vijayaraghavalu, Y. Gao, Manju Saraswathy, V. Labhasetwar, A. Ghorpade, Reaching for the Stars in the Brain: Polymer-Mediated Gene Delivery to Human Astrocytes, Molecular Therapy-Nucleic Acids (2018), Vol.12, pp. 645-657 [impact factor: 8.886]

5. T. D?Ovidio, R. Roberts, D. Gautam, Z. Marks, Manju Saraswathy, J. Stansbury and D. Nair, Photopolymerization Kinetics of Methyl methacrylate with reactive and inert Nanogels, Journal of the Mechanical Behavior of Biomedical Materials (2018), Vol.85, pp. 218-224 [impact factor: 3.902] 6. Manju Saraswathy, J. Stansbury and D. Nair, Thiol-functionalized nanogels as reactive plasticizers for crosslinked polymer networks, Journal of the Mechanical Behavior of Biomedical Materials (2017), Vol. 74, pp. 296-303 [impact factor: 3.902] 7. V.V.K. Venuganti, M. Saraswathy, C. Dwivedi1, R.S. Kaushik, O.P. Perumal. Topical gene silencing by iontophoretic delivery of antisense oligonucleotide-dendrimer nanocomplex: Proof of concept in a skin cancer mouse model, Nanoscale (2015) Vol. 7, pp. 3903-3914 [impact factor: 6.97]

M. Saraswathy and S. Gong, Recent developments in the co-delivery of siRNA and small molecule drugs for cancer treatment, Materials Today (2014), Vol 17, pp. 298-306 [impact factor: 24.372]

M. Saraswathy and S. Gong, Different strategies to overcome multidrug resistance, Biotechnology Advances (2013), Vol 31, pp. 1397???1407. [impact factor: 12.831]

S. Manju and K. Sreenivasan, Enhanced Drug Loading on Magnetic Nanoparticles by Layer-by-Layer Assembly using Drug Conjugates: Blood Compatibility Evaluation and Targeted Drug Delivery into Cancer cells, Langmuir (2011), Vol 27, pp. 14489???14496. [impact factor: 3.683]

S. Manju, C. P. Sharma, K. Sreenivasan, Targeted coadministration of sparingly soluble paclitaxel and curcumin into cancer cells by surface engineered magnetic nanoparticles, Journal of Materials chemistry (2011), Vol 21, 2011, pp.15708-15717. [impact factor: 5.047]

S. Manju and K.Sreenivasan, Gold Nanoparticles Generated and Stabilized by Water-soluble Curcumin-Polymer Conjugate: Blood Compatibility evaluation and Targeted drug delivery on to Cancer cells, Journal of Colloid and interface Science (2011), Vol 368, pp.144-151. [impact factor: 6.361]

S. Manju and K. Sreenivasan, Synthesis and characterization of a cytotoxic cationic polyvinylpyrrolidone-curcumin conjugate, Journal of Pharmaceutical Sciences (2011), Vol 100, pp. 504-511. [impact factor: 3.197]

S. Manju and K. Sreenivasan, Conjugation of curcumin onto hyaluronic acid enhances its aqueous solubility and stability, Journal of Colloid and interface Science (2011), Vol 359, pp. 318-325. [impact factor: 6.361]

S. Manju and K. Sreenivasan, Hollow microcapsules built by Layer by Layer assembly for the encapsulation and sustained release of curcumin, Colloids and Surfaces B: Biointerfaces (2011), Vol 82, pp.588-593. [impact factor: 3.973]

S. Manju and K. Sreenivasan, Detection of glucose in synthetic tear fluid using dually functionalized gold nanoparticles, Talanta (2011), Vol 85, pp. 2643-2649. [impact factor: 4.916]

M. Saraswathy, Chirathodi Vayalappil Muraleedharan, Adathala Rajeev, Attipettah Jayakrishnan, Roy Joseph, Evaluation of alginate dialdehyde cross-linked gelatin hydrogel as a biodegradable sealant for polyester vascular graft, Journal of Biomedical Materials Research: Part B Applied Biomaterials (2011), Vol. 98B, pp.139-149. [impact factor: 2.674]

S. Manju, P. R. Hari, K. Sreenivasan, Fluorescent molecularly imprinted polymer film binds glucose with concomitant changes in fluorescence, Biosensors and Bioelectronics (2010), Vol 26, pp.894-897. [impact factor: 9.518]

S. Manju and K. Sreenivasan, Layer-by-Layer modification of Poly (methyl methacrylate) intra ocular lens: Drug delivery applications, Pharmaceutical Development and Technology (2010), Vol 15, pp.379-385. [impact factor: 2.347]

S. Manju, M. Antony, K. Sreenivasan, Synthesis and evaluation of hydrogel that binds glucose and releases ciprofloxacin, Journal of Material Science (2010), Vol 45, pp. 4006-4012. [impact factor: 3.442]

Reviewed CRG proposals for SERB and DBT-DFG proposals for DBT

Journal of agricultural and food chemistry

Artificial cells, nanomedicine and biotechnology

Research and report in transdermal drug delivery

International journal of nanomedicine

Journal of nanopharmaceutics and drug delivery

Journal of biomedical nanotechnology

Journal of materials chemistry B

New journal of chemistry

Carbohydrate polymers

Journal of colloid and interface Science

Chitra ACryloSorb; Respiratory Secretion Solidification System (Technology transfered to Romsons Scientific and Surgical Pvt. Ltd., Agra, India)

Article

1
3. K. Borgmann J.Proulx, C. Joshi, S. Vijayaraghavalu, Manju Saraswathy, V. Labhasetwar, A. Ghorpade, Arginine-Modified Polymers Facilitate Poly (Lactide-Co-Glycolide)-Based Nanoparticle Gene Delivery to Primary Human Astrocytes, International Journal of Nanomedicine, 2020,
2
Sankar, P. R., Lathikumari, S. S., Manju Saraswathy, Superabsorbent Polymer Sponge for Saliva Absorption Pad, Journal of Advanced Oral Research, 2023,
3
Manju Saraswathy, Komath, M., Ragini, D. D., SomanPillai SarojiniAmma, P., Lathikumari, S. S., & Akhandanandan, M. N. , Bactericidal Activity of Superabsorbent Polymer Granules for Their Applications in Respiratory Fluid Solidification Systems, ACS Nano, 2023,
4
, V.V.K. Venuganti, M. Saraswathy, C. Dwivedi1, R.S. Kaushik, O.P. Perumal. Topical gene silencing by iontophoretic delivery of antisense oligonucleotide-dendrimer nanocomplex: Proof of concept in a skin cancer mouse model, Nanoscale (2015) Vol. 7, pp. 3903-3914 [impact factor: 6.97], , ,
5
, M. Saraswathy, G. T. Knight, Srikanth Pilla, R. S. Ashton and S. Gong, cRGD-conjugated nanoparticles formed by ??CD-PAMAM-PEG for targeted cancer therapy, Colloids and Surfaces B: Biointerfaces (2015) Vol. 126,, , ,
6
, M. Saraswathy, J. Stansbury and D. Nair, Synthesis and Characterization of Water Dispersible Siloxane Nanogels: A Novel Technique to Control Surface Characteristics and Drug Release Kinetics, Journal of Material Chemistry B (2016) Vol. 4, pp. 5299-5307 [impact factor: 5.047], , ,
7
, M. Saraswathy, J. Stansbury and D. Nair, Thiol-functionalized nanogels as reactive plasticizers for crosslinked polymer networks, Journal of the Mechanical Behavior of Biomedical Materials (2017), Vol. 74, pp. 296-303 [impact factor: 3.485], , ,
8
, J. Griffin, S. Cheng, M. Saraswathy, D. Nair, T. Hayashi, D. Carson and D. Simberg, Cell penetrating peptide CGKRK mediates efficient and widespread targeting of bladder mucosa following focal injury, Nanomedicine:NBM (2017), Vol. 13, pp.1925-1932 [impact factor: 5.57], , ,
9
, T. D Ovidio, R. Roberts, D. Gautam, Z. Marks, M. Saraswathy, J. Stansbury and D. Nair, Photopolymerization Kinetics of Methyl methacrylate with reactive and inert Nanogels, Journal of the Mechanical Behavior of Biomedical Materials (2018), Vol.85, pp. 218-224 [impact factor: 3.485], , ,
10
, C. R. Joshi, V. Raghavan, S. Vijayaraghavalu, Y. Gao, M. Saraswathy, V. Labhasetwar, A. Ghorpade, Reaching for the Stars in the Brain: Polymer-Mediated Gene Delivery to Human Astrocytes, Molecular Therapy-Nucleic Acids (2018), Vol.12, pp. 645-657 [impact factor: 5.919], , ,

Chapter

1
Manju. Saraswathy, V. Krishnaswami, Deepu. D. Ragini, Biomaterials for Hard Tissue Engineering: Concepts, Methods, and Applications., Book: Biomaterials in Tissue Engineering and Regenerative Medicine, From Basic Concepts to State of the Art Approaches, , Publisher: Springer Nature Singapore Pvt. Ltd.
2
Manju Saraswathy and David Oupicky, Endo-lysosomal escape into the cytosol, Book: Drug Delivery Across Physiological Barriers, , Publisher: Pan Stanford Publishing Pvt. Ltd

Review

1
Manju Saraswathy and S. Gong,, Recent developments in the co-delivery of siRNA and small molecule drugs for cancer treatment, Materials Today, 2014, Vol 17, pp. 298-306, https://doi.org/10.1016/j.mattod.2014.05.002
2
Manju Saraswathy and S. Gong,, Different strategies to overcome multidrug resistance, Biotechnology Advances, 2013, Vol 31, pp. 1397?1407, https://doi.org/10.1016/j.biotechadv.2013.06.004