Dr. Cibin T. R.
Associate Professor
Phone : 0471-2524178 (O), 98462 18889 (Cell)

Academic Qualifications

Ph.D., Biochemistry, University of Kerala, Thiruvananthapuram. 2011.

M.Phil., Biochemistry, University of Kerala, Thiruvananthapuram. 2004.

M.Sc., Biochemistry, University of Madras, Chennai. 2002.

B.Sc., Biochemistry, University of Madras, Chennai. 2000.

Professional Record

Associate Professor, Department of Biochemistry, SCTIMST. July 2021 - till date

Assistant Professor, Department of Biochemistry, SCTIMST. June 2018 - June 2021

Project Scientist, Kerala University of Fisheries and Ocean Studies (KUFOS), Panangad, Kochi, Kerala, India. 2016-2018

Post Doctoral Scholar, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. 2014-2016

Post Doctoral Scholar, Case Western Reserve University, Cleveland, OH, USA 2011-2014

ICMR-Senior Research Fellow, Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, India. 2008-2011

Junior Research Fellow, Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, India. 2004-2008

Lecturer, Department of Biochemistry, Govt. College, Kariavattom, Thiruvananthapuram, Kerala, India. 2002

Awards

Best Research Poster Award at 11th Indian Fisheries and Aquaculture Forum, Central Institute of Fisheries Technology, Cochin, Kerala, India. 21-24 November 2017.

Best Research Poster Award at Research Showcase- 2014, Case Western Reserve University, Cleveland, Ohio, USA. 18 April 2014.

Research Paper entitled - UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation? published in Journal of Biological Chemistry showcased in National Eye Institute (NEI), US Govt. website. (Link: https://nei.nih.gov/news/briefs/uv_cataract)

Area of Interest

Role of Advanced Glycation Endproducts (AGEs) in Tissue Fibrosis.

Membership

Life member, Indian Science Congress Association, India

Life Member, Society of Biological Chemists, India

Life Member, Academy of Cardiovascular Sciences, India

Life Member, Kerala Academy of Sciences

Life Member, Kerala Numismatic Society, India

On-going Projects

Role of S100 proteins in Cardiac Fibrosis. Role: Principal Investigator. Funding: ICMR. 2022-2025

Genetic Architecture of Parkinson's Disease in India. Role: Co-Investigator. Funding: Michael J Fox Foundation, USA. 2019-2022

Projects Completed

AGE modification of basement membrane: Implications in neurodegenerative diseases. Role: Principal Investigator. Funding: SCTIMST Seed fund. 2019-2021

Development of Real-time PCR assay for detection of SARS-COV2. Role: Co-Investigator. Funding: SCTIMST-TDF. 2020-2021

Professional Experience

Training

Training programme on Quality Management Systems and Internal Audit in Medical Laboratories as per ISO 15189:2102. Duration: 4 days. 2019.

Presentations

TGFb2 mediated Epithelial to Mesenchymal Transition: Role of AGE-RAGE interaction. 12th Young Investigator Meeting (YIM) 2020 held from 14-18 February 2020 at Mahabalipuram, Chennai.

Invited talks

Kynurenines and AGE synthesis. International seminar on recent trends in Omics, Regenerative and Precision Medicine: Interface between Infectious and non-infectious diseases organized by Department of Zoology, University of Kerala, Trivandrum. 23 July 2022.

Gene editing in research. International seminar on Life Sciences organized by Department of Biotechnology, Government College, Kariavattom, Trivandrum. 04 March 2022

Gene Knockout, Knockdown and Knockin. Online Faculty Development Programme (FDP) organized by Department of Biochemistry and Molecular Biology, Central University of Kerala, Kasaragod. 18 January 2022

Advanced Glycation Endproducts and Kynurenine Pathway. Webinar organized by GN Ramachandran Science Club, Mar Athanasios College of Advanced Studies Tiruvalla (MACFAST). 06 Jan 2021

Advanced Glycation Endproducts and Fibrosis. National Seminar on `Novel Prospects in Biotechnology?. Organized by Department of Botany and Biotechnology, AJ College of Science and Technology, Thiruvananthapuram. 7th November 2019.

Kynurenine-mediated ascorbic acid oxidation and Advanced Glycation Endproducts. National Seminar on `Recent Approaches in Biochemical Research?. Organized by Department of Biochemistry, University of Kerala, Thiruvananthapuram on 5th November 2019.

Glycation and Fibrosis. National Symposium on Advances in Biosciences (SEIB 2019). Organized by Inter-University Centre for Evolutionary and Integrative Biology, University of Kerala, Thiruvananthapuram.

Glycation and Fibrosis. National Seminar on Biomedical Research: Changing Paradigms across time. Organized by Department of Biochemistry, Govt. College, Kariavattom, Thiruvananthapuram. 1st February 2019.

Reviewer

Reviewer, PLOS One

Publications

Article

1
Cibin T. Raghavan, Mi-Hyun Nam, Rooban B. Nahomi, Andrew J.O. Smith, Mina B. Pantcheva, Mareen Smuda, Micheal I. Wormstone, Marcus A. Glomb and Ram H. Nagaraj., AGEs in extracellular matrix promote the TGFb2-mediated epithelial to mesenchymal transition of lens epithelial cells: Implications for secondary cataracts., IMARS Highlights, 2019, 14(3): 14-17
2
Cibin T. Raghavan and Ram H. Nagaraj, AGE-RAGE interaction in the TGFb2-mediated epithelial to mesenchymal transition of human lens epithelial cells., Glycoconjugate Journal, 2016, 33(4): 631-643, https://link.springer.com/article/10.1007/s10719-016-9686-y
3
Cibin T. Raghavan, Mareen Smuda, Andrew J. O. Smith, Scott Howell, Dawn G. Smith, Annapurna Singh, Pankaj Gupta, Marcus A. Glomb, I. Michael Wormstone and Ram H. Nagaraj., Advanced Glycation Endproducts in Human Lens Capsule Promote the TGFb2-mediated Epithelial to Mesenchymal Transition of Lens Epithelial Cells: Implications for Posterior Capsule Opacification., Aging Cell, 2016, 15(3): 465-476, https://onlinelibrary.wiley.com/doi/abs/10.1111/acel.12450
4
Ram H. Nagaraj, Rooban B. Nahomi, Niklaus Mueller, Cibin T. Raghavan, David Ammar and J. Mark Petrash., Therapeutic Potential of a-Crystallin., Biochemica et Biophysica Acta - General Subjects, 2016, 1860 (1 Pt B):252-257, https://www.sciencedirect.com/science/article/pii/S0304416515000926?via%3Dihub
5
Thomas Holm, Cibin T. Raghavan, Rooban Nahomi, Ram H Nagaraj and Line Kessel., Effects of photobleaching on selected advanced glycation end products in the human lens., BMC Research Notes, 2015, 8(1):5, https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-015-0977-3
6
Mareen Smuda, Christian Henning, Cibin T. Raghavan, Kaid Johar, Abhay R. Vasavada, Ram H. Nagaraj and Marcus A. Glomb., Comprehensive Analysis of Maillard Protein Modifications in Human Lenses: Effect of Age and Cataract., Biochemistry, 2015, 54 (15): 2500-2507, https://pubs.acs.org/doi/abs/10.1021/bi5013194
7
Mikhail Linetsky*, Cibin T. Raghavan*, Kaid Johar, Vincent M. Monnier, XingJun Fan, Abhay R. Vasavada and Ram H. Nagaraj. *Equal Contributions, UVA light-excited kynurenines oxidize ascorbate and modify lens proteins through the formation of advanced glycation end products: implications for human lens aging and cataract formation., Journal of Biological Chemistry, 2014, 289(24):17111-17123, http://www.jbc.org/content/289/24/17111.full
8
Michael A. DiMauro, Sandip K. Nandi, Cibin T. Raghavan, Rajiv Kumar Kar, Benlian Wang, Anirban Bhunia, Ram H. Nagaraj, and Ashis Biswas., Acetylation of Gly1 and Lys2 promotes aggregation of human gD-crystallin., Biochemistry, 2014, 53(46):7269-7282, https://pubs.acs.org/doi/abs/10.1021/bi501004y
9
Gayathri Devi D, Cibin T. R and Annie Abraham, Bis (3, 5-diiodo-2, 4, 6-trihydroxyphenyl) squaraine photodynamic therapy induces in vivo tumor ablation by triggering cytochrome c dependent mitochondria mediated apoptosis., Photodiagnosis and Photodynamic Therapy, 2013, 10(4):510-517, https://www.sciencedirect.com/science/article/pii/S1572100013000537
10
Rooban B. Nahomi, Benlian Wang, Cibin T. Raghavan, Oliver Voss, Andrea Doseff, Puttur Santhoshkumar and Ram H. Nagaraj., Chaperone peptides of a-crystallin inhibit epithelial cell apoptosis, protein insolubilization and opacification in experimental cataracts., Journal of Biological Chemistry, 2013, 288(18) 13022-13035, http://www.jbc.org/content/288/18/13022.long