Ph.D;Jiwaji University;2006.

M.Sc;Jiwaji University;2000.

B.Sc;Jiwaji University;1998.

Scientist G since July 2022

Scientist -in Charge Division of Thrombosis Research 2019 -

Scientist F Feb 2018- June 2022

Scientist E;TRU, BMT wing SCTIMST, Trivandrum;from 2015-18

Scientist D;TRU, BMT wing SCTIMST, Trivandrum;from 2012-15

Scientist C;TRU, BMT wing SCTIMST, Trivandrum;from 2008-12

PDF;CMC, SCTIMST, Trivandrum;2007.

SRF;CMC, SCTIMST, Trivandrum;2006.

GATE. University Fellowship, Travel awards

3 D Bioprinting, proteomics, blood material interaction and stem cell research.

Dr. Unnikrishnan S Plastic surgeon, Ames clinic , Trivandrum

Prof. Harikrishnan S , Department of Cardiology, SCTIMST

Dr. Sruthi S Nair, Department of Neurology, SCTIMST

3 D Bioprinting, skin tissue engineering Endothelial cell research and platelet proteomics.

Application No 201941031304: Cell growth Enhancing bioink formulation for 3D bioprinted construct.

Application No 202041012139: Multicomponent peptide based bioink for bioprinting tissue constructs

Application No 201941042420: A dual barrier device for the collection of blood and isolation of blood components

Application No 202041028674: Development of filter housing for a leukodepletion filter unit

Application No 202041015783: Oropharyngeal swab

Application No 202041015212: A kit for the rapid detection of IgG/IgM antibodies using immunochromatographic techniques

Application No 202041020015: Universal Transport Medium ?

Application No 201941043077 : A Biological fluid component separator and the mechanism thereof

Jiwaji University Research Fellowship.

DBT-IISC postdoctoral Fellowship.

International Society of stem cell research

Society for Biomaterials

Fellow member of Society of Applied Biotechnology

Society for Cardiovascular Research

The Cytometry Society.

International Society for Atherosclerosis Research.

Exploring the effect of secretome of platelet-mesenchymal stem cells spheroids on angiogenesis and healing in chronic wounds : DST-SERB ongoing

in- vivo evaluation of 3D bioprinted skin tissue construct

3D Bioprinting of Skin tissue construct: DST-TRC, PI,Hydrogel as bioink was synthesized, characterized and optimized for printability. Dermal epidermal culture was optimized, constructs are cultured and analysis of functional markers are ongoing.

Development of the assay platform and sensing device for Prothrombin Time/INR monitoring DST-TRC funded, PI, Technology is transferred to Agappe Diagnostic Pvt Ltd, Device improvement is ongoing for increasing the sensitivity of the device.

PRP isolation Kit, TDF, Co-I. Device prototype has been developed and studies are ongoing

3D Bioprinting of Liver, DST-TRC Co-I, 2016-19. Cellular studies for the collagen based bioink formulated as well as explored the differentiation of ADMSCs to hepatic like cells in order to establish an alternative cell source for the hepatic regeneration. Cells functionality and viability was proven based on the live dead assay and functional assay like cyto P-450, albumin secreation, cardiogreen uptake, glycogen storage and urea production.

Development of Leukodepletion filter, DST-TRC, Co-PI, 2017-20. Different batches of filters were tested for blood filtration and best one with 100% depletion was identified and is taken forward for the further studies. Filter material was modified to improve filtration efficiency.

role of platelet proteins in atherosclerosis.

Monocyte proteome profiling in diabetic subjects. Proteomic profiling of monocytes from diabetic subjects were done and analyzed for the proteins causing cardiovascular diseases in diabetic subjects.

Coronary Artery Disease in the Young: KSCSTE funded, Co-I 2010-14: Platelet activation status in young patient was evaluated and platelet monocytes interaction studies were done using CD62 and CD14. Inflammatory market analysis in young cardiac patient was also carried out. Monocytes phenotypes were also analyzed using CD14 and CD16 antibodies using flowcytometry. Two publications as co author and three conference paper as co author was the outcome of this project.

Quantum dots as a drug carrier in cardiovascular diseases . DST funded, Co-PI ,2011-2014 : CdSe/ZnS based quantom dots were synthesized, characterized and tagged with specific antibody. Encapsulation of the targeted system and effect on endothelial cells were studied in-vitro. Biocompatibility studies on the synthesized QDs were also carried out. QDs were found to be specific. Three papers were published and one paper was presented in an International conference and was published in the proceedings.

Role of platelet proteins on the Endothelial Cells and Smooth Muscle Cells proliferation: SCTIMST funded,PI, 2012-14. Platelet proteome was isolated and effect of platelet proteome on endothelial cells and smooth muscle cell proliferation was evaluated in-vitro. Activated platelet proteome was assayed to analyze the variation from the resting healthy platelets.

Do platelet in patients with type II diabetes secretes proteins that can activate aortic endothelial cells funded by KSCSTE , PI, 2014-17. Proteomic profiling of twenty subjects from each group (diabetic and healthy) were done. Data was analyzed by using PD quest 2D gel analysis software. Significant differences between the groups were observed. Mass spectrum analysis was done for the samples. Western blot analysis was done for PF4, beta thromboglobulin, secretogranin, cyclophilin A. Mass pack analysis of data revealed the up-regulation of inflammatory and oxidative stress pathways in the diabetic subjects. One paper was published as a outcome of this project. Two man power was trained and two conference paper was presented and two workshop was attended.

MPhil : Binnu Gangadharan: PROFILING OF THE PLATELET PROTEINS IN ATHEROSCLEROSIS RISK FACTOR GROUP: A COMPARATIVE ANALYSIS.2011-12

Sahana S : Proteomic Profiling of Released Platelet Protein in Plasma from Healthy and Diabetic Subjects. 2012 -13

Serene Hilary: Role of platelets proteins on endothelial cell dysfunction 2013-14

Deepa S :platelet monocyte interactions in diabetic subjects

Rasia S : ADMSCs differentiation to hepatic like cells 2016-17

Anusree KS :ADA-Gelatin-Fibrin Hydrogel for HepG2 growth. 2017-18

Gayathri PJ : 3D BIOPRINTED HYDROGEL SYSTEM FOR SKIN TISSUE ENGINEERING 2018-19

Athira KR (Co-Guide): leukodepletion filter

3D Bioprinting of skin tissue construct: Dual layer skin tissue construct were printed and analyzed in-vitro and in-vivo. In-vitro studies showed functional skin markers and the preliminary in-vivo studies demonstrated better wound healing.

Mesenchymal stem cells and activated platelets, role of secretome in wound healing : MSCs will be induced by activated platelets. MSCs secrtome will be analyzed and wound healing efficiency will be analyzed.

Development of the PT INR assay platform : A novel device is developed to measure prothrombin time . Initial experiments showed exciting results. Research is in progress to achieve an accurate point of care device

Role of activated proteins in endothelail dysfunction

Q-dots as drug carrier in cardiovascular diseases

ADMSCs as a source of hepatic like cells

Dr. Renjith P Nair

Mr. Anil Kumar V

Ms Priyanka A

Ms. Safeena

Ms. Deepa S

Ms. Athira KR

Ms. Sajitha

Invited faculty/speaker in the 11th Meeting of The Cytometry Society held on 29th Oct-1st Nov 2019 organized by AIIMS New Delhi

Delivered an invited talk on ?Diabetes and Cardiovascular Diseases: Platelets the linking bridge? in the International Seminar on Recent Biochemical approaches in Therapeutics, organized by University of Kerala on 11-13th Dec 2019

Delivered an invited talk on Current Strategies for SARS-CoV-2 Prevention, Diagnosis and Cure in a National Webinar on Current strategies and challenges of Diagnosis, Treatment and Control of Covid -19 on 15-16th July 2020, organized by SOS Biochemistry, Jiwaji University

Invited faculty for flow workshop on Basics of flowcytometry for Jiwaji University on 20.01.2021

Delivered a talk as a Resource person in UGC Human Resource Development Centre, Guru Ghasidas Vishwavidhyalaya, Chattisgarh on 25th Feb 2021.

Delivered an invited talk on ?3D Bioprinters: Print the future? in an online lecture series ?Frontiers in genomics, Molecular Diagnostics and Future Medicine organized by University of Kerala on Feb 14 2022

Delivered an invited talk on ?3D Bioprinting The promising Technology in Regenerative Medicine? in an International webinar on Emerging Infectious diseases, Molecular Diagnostics, Vaccines and Future Medicine organized by the Kerala Academy of Science and central University of Kerala on 17th March 2022

Delivered an invited talk on 3D Bioprinting Dimensions to Life in a lecture series organized by Indian Women Scientist Association, BRNE and ICT Mumbai on 19th March 2022

Invited faculty in institute industrial partnership programme of SCTIMST for blood compatibility evaluation

>40

Anugya Bhatt*, Renjith P Nair, Rashmi R, Riya Raju, Rency Geeverghese, Lekshmi P, Product evaluation: blood compatibility studies, Editor(s): P.V. Mohanan, In Woodhead Publishing Series in Biomaterials, Biomedical Product and Materials Evaluation, Woodhead Publishing, 2022, pages 435-459, ISBN 9780128239667, https://doi.org/10.1016/B978-0-12-823966-7.00022-0.

Renjith P Nair, Lekshmi P, Anugya Bhatt*, Blood-derived products, Editor(s): P.V. Mohanan, In Woodhead Publishing Series in Biomaterials, Biomedical Product and Materials Evaluation, Woodhead Publishing, 2022, Pages 231-257, ISBN 9780128239667, https://doi.org/10.1016/B978-0-12-823966-7.00015-3.

JA Sekar, RK Athira, TS Lakshmi, S Velayudhan Anugya Bhatt, PR Anil Kumar, Naresh Kasoju, 3D Bioprinting in Tissue Engineering and Regenerative Medicine: Current Landscape and Future Prospects. Biomaterials in Tissue Engineering and Regenerative , 2021

Rathina Vel, Anugya Bhatt*, A. Priyanka, Ashna Gauthaman, V. Anilkumar, A.S. Safeena, Ranjith S, DEAE- Cellulose-based composite hydrogel for 3D printing application: Physicochemical, mechanical, and biological optimization, Materials Today Communications, Volume 33, 2022, 104335, ISSN 2352-4928, https://doi.org/10.1016/j.mtcomm.2022.104335. (https://www.sciencedirect.com/science/article/pii/S2352492822011771)

Rency Geevarghese, Lakshmi T. Somasekharan, Anugya Bhatt, Naresh Kasoju, Renjith P. Nair, Development and evaluation of a multicomponent bioink consisting of alginate, gelatin, diethylaminoethyl cellulose and collagen peptide for 3D bioprinting of tissue construct for drug screening application, International Journal of Biological Macromolecules, Volume 207, 2022, Pages 278-288, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2022.02.191.

Rashmi Ramakrishnan, Naresh Kasoju, Riya Raju, Rency Geevarghese, Ashna Gauthaman, Anugya Bhatt*, Exploring the Potential of Alginate-Gelatin-Diethylaminoethyl Cellulose-Fibrinogen based Bioink for 3D Bioprinting of Skin Tissue Constructs, Carbohydrate Polymer Technologies and Applications, Volume 3, 2022, 100184, ISSN 2666-8939, https://doi.org/10.1016/j.carpta.2022.100184.

Somasekharan, L.T., Raju, R., Kumar, S., Geevarghese, R., Nair, R.P., Kasoju, N., Bhatt, A., 2021. Biofabrication of skin tissue constructs using alginate, gelatin and diethylaminoethyl cellulose bioink. International Journal of Biological Macromolecules 189, 398???409. https://doi.org/10.1016/j.ijbiomac.2021.08.114

R Sultana, A Bhatt Differentiation of Human Adipose Tissue Derived Mesenchymal Stem Cells to Functional Hepatocytes like Cells: Exploring the Niche and Admscs Conditioned Media. Archives of Clinical and Biomedical Research 5 (2), 169-184

Sarath S Nair, Rakhi MR, Lakshmi K S Anugya Bhatt Analysis of Whole Blood Prothrombin Time/ International Normalized Ratio Using Image Processing. Research in Medical Sciences and Engineering 9 (2), 999-1006

V Maya, JE Kaviyil, DK Ponnambath, RP Nair, A Bhatt, R Pilankatta, ... Evaluation of diagnostic accuracy of developed rapid SARS-COV-2 IgG antibody test kit using novel diluent syst VirusDisease 32 (1), 78-84

PV Mayuri, A Bhatt, S Arumugam, R Parameswaran. An explicit correlation between surface functionality, wettability, and leukocyte removal by electrospun filter media. - Materials Today Communications, 2021. 26:102075,ISSN 2352-4928,https://doi.org/10.1016/j.mtcomm.2021.

Reshmi R, Anusree KS, Roy Joseph and Anugya Bhatt*. Scaffold for Liver Tissue Engineering: Exploring the Potential of Fibrin Incorporated AlginateDialdehyde???Gelatin Hydrogel. International J of Biological macromolecules, 2021. 166; 998-1008.[IF 5.2]

Lakshmi T. Somasekharan, Naresh Kasoju, Riya Raju, Anugya Bhatt*, Formulation and characterization of alginate dialdehyde, gelatin and platelet rich plasma based bioink for bioprinting applications. Bioengineering, 2020 7 (3), 108

Deepa S and Anugya Bhatt*, A preliminary study on monocyte-platelet interactions in diabetic subjects leading to phenotypic changes in monocytes - ijar, 2020 [SJIF 6.03]

P. V. Mayuri, Anugya Bhatt, A. Sabareeswaran & P. Ramesh. Effect of membrane parameters and filter structure on the efficiency of leukocyte removal by electrospun poly(ethylene-co-vinyl alcohol) membranes, Journal of Biomaterials Science, Polymer Edition,2020 DOI: 10.1080/09205063.2020.1851559.

P.V. Mayuri, Anugya Bhatt and P. Ramesh ???Glycine integrated zwitterionic hemocompatible electrospun poly(ethylene-co-vinyl alcohol) membranes for leukodepletion??? Biomed. Phys. Eng. Express 6, 055019, 2020. IF 1.1

P. V. Mayuri, Anugya Bhatt and P. Ramesh, ???Investigation of the potency of leukodepletion filter membranes immobilized with bovine serum albumin via polydopamine spacer???, SN Applied Sciences, 2:1738, 2020.

P.V. Mayuri, Anugya Bhatt and P.Ramesh, ???Sulfobetaine-functionalized electrospun poly(ethylene-co-vinyl alcohol) membranes for blood filtration???, Journal of Applied Polymer Science, 136, 47057, 2019.(I.F.=2.52).

Hilary, Serene; Shahna, S; Kesavadev, Jothydev; Bhatt, Anugya*; Platelet proteins from diabetic subjects cause phenotypic changes in endothelial cells in-vitro. International J of Life Sciences and Pharma Research 7, 61-71, 2017. IF 0.9 SJIF 7.578

Madathil, Bernadette K; Kumary, TV; Bhatt, Anugya; Kumar, PR Anil; BIofunctionalised polycaprolactone fibrous mat as a transfer tool for cell sheet engineering. Fibers and Polymers 18 (11), 2094-2101, 2017. [IF 1.59]

Mayuri, PV; Bhatt, Anugya; Joseph, Roy; Ramesh, P; Effect of photografting 2-hydroxyethyl acrylate on the hemocompatibility of electrospun poly (ethylene-co-vinyl alcohol) fibroporous mats.Materials Science and Engineering: C 60, 19-29, 2016. IF 5.080

George, Reema; Bhatt, Anugya; Narayani, Jayakumari; Thulaseedharan, Jissa Vinoda; Sivadasanpillai, Harikrishnan; Tharakan, Jaganmohan A; Enhanced P-selectin expression on platelet-a marker of platelet activation, in young patients with angiographically proven coronary artery disease. Molecular and cellular biochemistry 419 (1-2), 125-133. 2016. IF 2.561

Mayuri, PV; Anugya, Bhatt; Sabareeswaran, A; Ramesh, P; A novel leukodepletion filter from electrospun poly (ethylene-vinyl alcohol) membranes and evaluation of its efficiency. International Journal of Polymeric Materials and Polymeric Biomaterials 65 183-190, 2016. [IF 2.127]

George, Reema; Sivadasanpillai, Harikrishnan; Jayakumari, Narayani; Bhatt, Anugya; Thulaseedharan, Jissa V; Tharakan, Jaganmohan A; Circulating thrombotic risk factors in young patients with coronary artery disease who are on statins and anti-platelet drugs. Indian Journal of Clinical Biochemistry 31 (3), 302-309, 2016. . [IF 1.14]

A Bhatt, LK Krishnan, Higher affinity of plasma fibrinogen for newly exposed glycoprotein IIb (CD41) on activated platelets could cause reduced anti-CD41 bindingNewly exposed membrane. International Journal of Blood Research 2015;1-8

DBT

MDPI

Elsevier

PT/INR to Agappe Dignostics