Projects

Centrifugal Blood Pump with Blood Flowmeter

  • Extracorporeal Cardiopulmonary Bypass is a technique where the patient heart has to be stopped or bypassed during open heart surgery.
  • The functions of the heart and lungs will be replaced by blood pump and oxygenator respectively.
  • Roller pumps are cost effective for bypass, but causes blood damage.
  • Centrifugal blood pump reduces blood damage substantially. Blood flowmeter is used for measuring the flow output from the pump
Phase Principal Investigator:

Mr. Vinodkumar V

Principal Clinical Investigator:

Dr. Vivek V Pillai

Para-Corporeal Left Ventricular Assist Device

  • A mechanical pump used to support heart function in patients who have weakened hearts.
  • The device takes blood from the left ventricle of the heart and helps pump it to the body and vital organs, just as a healthy heart would.
  • This can be used in patients waiting for heart replacement or patients having problems during surgery where heart will recover if it is allowed to relax for few days.
Phase Principal Investigator:

Mr. D. S. Nagesh

Principal Clinical Investigator:

Dr. K Jayakumar

Aortic Stent for Endovascular treatment of Thoracic Aortic Aneurysm

  • Used as an alternative to conventional surgical repair of aortic aneurysms (localized blood filled balloon like bulge in the wall of large arteries).
  • The device is tubular fabric structure with metal reinforcement which can be delivered to the site using catheters
  • The patient recovers fast and it requires only a shorter period of hospital stay.
Phase Principal Investigator:

Mr. Sujesh S

Principal Clinical Investigator:

Dr. Unnikrishnan M

Deep Brain Stimulator System for Movement Disorders

  • Parkinson's disease (PD) patients suffer from a variety of movement related disorders such as tremors, stiffness of limbs, slowness of movements and poor balance.
  • Low energy electrical stimulation of certain regions of brain using electrodes implanted in the brain controls these symptoms.
  • Deep Brain Stimulator employs a pulse generator and a set of platinum electrodes to achieve the required effects.
Phase Principal Investigator:

Mr. Muraleedharan C.V.

Principal Clinical Investigator:

Dr. Asha Kishore

Leukocyte (WBC) Reduction Filter

  • Presence of White Blood Cells (WBC) in transfused blood creates many complications to the recipients.
  • Leuko-reduction is the removal of white blood cells (or leukocytes) from the blood or blood components supplied for blood transfusion.
  • The device employs special membranes which attracts and traps WBC as blood passes through it.
Phase Principal Investigator:

Dr. P Ramesh

Principal Clinical Investigator:

Dr. Sulochana.P.V.

Bio prosthetic Heart Valve

  • Artificial heart valves are devices used for replacing diseased / damaged natural valves of the heart.
  • They function as check valves which ensure unidirectional flow of blood in the heart and circulatory system
  • Bio prosthetic heart valves are artificial valves made from materials of biological origin and are preferred in elderly patients.
Phase Principal Investigator:

Dr. P R Umashankar

Principal Clinical Investigator:

Dr. Vivek V Pillai

Bioactive inter-vertebral spacers for lumbar fusion

  • Instability of lower spine vertebrae due to spondylosis (spinal degeneration) and spondylitis (inflammatory arthritis that affects the spine) often lead to crippling pain.
  • Pain relief is achieved surgically by fusing the unstable portion of the spine or immobilizing the vertebral motion segment
  • The device helps in joining vertebral bodies through natural healing
Phase Principal Investigator:

Dr. Manoj Komath

Principal Clinical Investigator:

Dr. Prakash Nair

Bioactive Material Platform for Drug Delivery in bone

  • Bone and joint infections (Osteomyelitis) remain one of the most dreaded complications of orthopaedic surgery.
  • Bacteria adhere to implants, especially metals, making eradication of infection even more difficult.
  • Project aims at the development of a bioactive material platform having a novel bioceramic composition, which has tuned porosity and osteoconductivity
Phase Principal Investigator:

Dr. Harikrishna Varma

Principal Clinical Investigator:

Dr. Easwer H V

Intracranial Electrodes for use in acute and chronic Electro-Corticography for periods up to 15 days.

  • Epileptic seizures are the result of excessive and abnormal nerve cell activity in the certain regions of brain.
  • Intracranial electrodes are used for locating the epileptogenic regions of brain. They help to locate the regions that need to be removed by surgery for controlling epilepsy.
  • The device employ platinum electrodes with platinium - irridium alloy connection wires embedded in silicone rubber.
Phase Principal Investigator:

Mr. Jithin Krishnan

Principal Clinical Investigator:

Dr. Ramshekar Menon

Optical Peripheral Nerve Stimulator

  • Standard approach to stimulating human nerve cells uses electrical current.
  • Optical nerve stimulation overcomes many of the problems like pain associated with electrical stimulation: it requires no physical contact with the nerve cells.
  • Light source can be tuned to precisely hit a small desired area.
  • The project will focus on the feasibility of optical neural stimulation
Phase Principal Investigator:

Dr. R. S. Jayasree

Blood Derived Products

  • Products extracted from human blood and meant for various therapeutic applications
  • These include albumin, Factor VIII and Intravenous Immunoglobulin (IVIG).
  • The products will be validated to meet the requirements of European / Indian Pharmacopoeia
Phase Principal Investigator:

Dr. Lissy Krishnan

An injectable hydrogel for repair of cartilage injury and growth plate defects

  • The incidence of cartilage injury or damage is quite common and may be traumatic or degenerative.
  • The aim of the project is to develop injectable hydrogel for repairing damaged cartilages.
  • The gel can also be used as a vehicle to transport cartilage producing cells to the site.
Phase Principal Investigator:

Dr. Prabha D.Nair

Principal Clinical Investigator:

Dr. Vrisha Madhuri

3D Printing of Liver Tissue Constructs for In vitro Hepatotoxicity Testing

  • The evaluation of potential liver toxicity represents a crucial step in the development of new drugs.
  • Laboratory animals are used for carrying out these tests.
  • The 3D liver constructs can be used for preliminary screening of drugs for their liver toxicity and help reduce the use of laboratory animals for drug toxicity assays.
Phase Principal Investigator:

Dr. Anilkumar P. R.

Assay Platform and Sensing Device for PT / INR Monitoring

  • Most of the blood vessel disease patients and those with cardiovascular implants, management need continuous and lifelong use of anticoagulant and need a close monitoring of blood clotting time (Prothrombin Time-PT) regularly.
  • A home care monitoring system is planned in this project.
Phase Principal Investigator:

Dr. Anugya Bhatt

Principal Clinical Investigator:

Dr. Harikrishnan S

Chitosan / Alginate based Polymeric Wound Dressings for Controlled Antibiotic Delivery

  • Wound infection is a major concern in wound management
  • The polymeric wound dressing would be capable of in situ loading of antibiotics in it.
  • This will be more appropriate as it gives the clinician the freedom to choose the drug of his / her choice
Phase Principal Investigator:

Dr. Rekha M. R.

Fabrication of a wound healing matrix from porcine cholecystic - extracellular matrix

  • The extra cellular matrix, from tissues of animal origin after removal of unwanted cells, has a rich load of natural biomolecules that promote tissue regeneration.
  • The objective of the project is to fabricate a matrix from porcine tissues.
  • The extracellular matrix from gall bladder will be developed for wound healing applications.
Phase Principal Investigator:

Dr. T.V. Anil Kumar

Lint free absorbent dressing for surgical and highly exudating chronic wounds

  • The project aims at development of a non - toxic medical dressing having a high fluid holding capacity.
  • It will be fast wicking and lint free, even when cut or trimmed.
  • The medical dressing will have application in certain highly exudating chronic wounds.
Phase Principal Investigator:

Dr. Lynda V Thomas

Point of Care Devices for Infectious Diseases

  • Loop mediated isothermal amplification (LAMP) is a nucleic acid amplification technique which could be carried out using single temperature reaction set up.
  • The project attempts to develop a point of care device for detection of tuberculosis using the technique
Phase Principal Investigator:

Dr. Anoop Kumar T

Alginate scaffold with recombinant growth factors for enhanced wound healing

  • Growth factors are substances secreted by the body whose function is to stimulate the growth of the cells involved in wound healing and inflammation.
  • The project will be focusing on two recombinant growth factors, for its potential application in wound healing.
Phase Principal Investigator:

Dr. Anoop kumar T

Principal Clinical Investigator:

Dr. Padmakumar

Evaluation of biodegradable PLGC - fibrin hemostatic graft for skin regeneration

  • Skin tissue engineering approaches using an electro spun biodegradable polymer scaffold with appropriate degradation profile and physico - chemical properties will be developed as a scaffold.
  • Upon its implantation, undesirable contraction of the wound could be prevented.
Phase Principal Investigator:

Dr. Lissy Krishnan

Principal Clinical Investigator:

Dr. Prasanth Varkey

Atrial Septal Defect (ASD) Occluder

  • An Atrial Septal Defect (ASD) is an opening or a hole in the wall that separates the two upper chambers of the heart.
  • Conventional management technique is open heart surgery to close the hole.
  • A special metal alloy (NiTiNOL) mesh is taken to the site using a catheter and then deployed to close the hole.
  • Being a non - surgical procedure, the patient recovers fast and it requires a very short period of hospital stay.
Phase Principal Investigator:

Mr. Sujesh S

Principal Clinical Investigator:

Dr. S Bijulal

Radiopaque Liquid Embolization Device

  • Abnormal communication between small arteries and veins within the brain are described as arterio - venous malformation, causing seizures, intracranial bleeding, paralysis, visual loss or severe headache.
  • Such defects are sealed with special sealants which set on contact with blood.
  • A non-metallic sealant is planned in the project. This will help reduce MRI incompatibility.
Phase Principal Investigator:

Dr. Roy Joseph

Principal Clinical Investigator:

Dr. Jayadevan E R

Bacillus Species producing molecule against Methicillin Resistant Staphylococcus Aureus (MRSA)

  • MRSA is a bacterium that is tougher to treat because it is resistant to some commonly used antibiotics
  • A microbial strain which produces an antibacterial agent which is active against MRSA has been isolated
  • Project aims at detailed characterization of this antimicrobial molecule.
Phase Principal Investigator:

Dr. A Maya Nandkumar

Oral Insulin Delivery System

  • The basic appeal of oral hypoglycaemic agents is that most people would prefer a pill or an oral liquid to an injection.
  • However, insulin is a hormone, which is digested in the stomach and gut.
  • The project attempts to develop a strategy for oral delivery of insulin by suitably encapsulating to protect it during its traverse through the stomach.
Phase Principal Investigator:

Dr. Rekha M R

Flow Diverter Stent

  • Intracranial aneurysm is a condition in which weakness in the wall of a cerebral artery causes a localized dilation or ballooning of the blood vessel.
  • Flow diversion is an endovascular technique whereby the device is placed in the parent blood vessel to divert blood flow away from the aneurysm itself.
Phase Principal Investigator:

Mr. Sujesh S

Principal Clinical Investigator:

Dr. Santhosh K

Implantable Cardioverter Defibrillator

  • An Implantable Cardioverter Defibrillator (ICD) is a battery-powered device implanted under the skin of the chest, which is able to perform cardioversion, defibrillation and pacing of the heart.
  • Cardioversion is a procedure by which an abnormally fast heart rate (tachycardia) or other cardiac rhythm disorders are treated using electrical signals.
  • Defibrillation is a treatment for life-threatening cardiac fibrillation (unsynchronized contraction of heart muscles) using electrical shocks.
Phase Principal Investigator:

Mr. Muraleedharan C V

Principal Clinical Investigator:

Dr. Narayanan Namboodiri KK

Annuloplasty Ring for Mitral Valve Correction

  • The Annuloplasty ring is a rigid or flexible ring implanted around the mitral valve for reconstructive treatment of valvular insufficiency.
  • The implanted device enhances leaflet coaptation while preserving the native annular shape and motion.
Phase Principal Investigator:

Mr. Ranjith G

Principal Clinical Investigator:

Dr. Vivek V Pillai

Programmable Hydrocephalus Shunt

  • Hydrocephalus is the condition in which the cerebrospinal fluid (CSF) is accumulated within the brain. Due to this condition it may result in increased pressure inside the skull. It will result in various brain related problems especially in infants and older people. This condition is either due to birth defect or acquired later in the life. Hydrocephalus results in the conditions like Spina Bifida, Loss of consciousness, tiredness, irritability, drowsiness.
  • Hydrocephalus is treated by a surgical operation in which a shunt which connects the brain region to other parts of human body. Generally the CSF is drained to the peritoneal cavity. In this case a shunt is called Ventriculo Peritoneal (VP) shunt. Another type of shunt is Ventriculo-atrial (VA) shunt in which the fluid moves to right atrium of the heart.
Phase Principal Investigator:

Mr. Anoop Gopinathan

Principal Clinical Investigator:

Dr. Easwer H V

Wound Healing Matrix composed of Human-fibrin, Amniotic membrane & Hyaluronic acid

  • Combines three natural biological matrix components such as:
    i.   Fibrin- composite matrix which is hemostatic
    ii.   HA which hydrates the wound
    iii.   Amnion to use as an implantable biodegradable matrix to promote wound healing through guided tissue regeneration in vivo
Phase Principal Investigator:

Dr. Lissy K Krishnan

Principal Clinical Investigator:

Dr. Prasanth Varkey

3 D Printing of Skin Tissue Constructs

  • Aims to develop a skin construct
  • A polymer ink based fabrication using 3D bio printing techniques used for encapsulating skin cells like Keratinocytes, fibroblasts and melanocytes for skin regeneration
Phase Principal Investigator:

Dr. Anugya Bhatt

Principal Clinical Investigator:

-

Implantable Micro Infusion pump with Wireless Recharging System

  • An implantable micro infusion pump which can deliver drug to the region of interest such as peritoneal cavity, spinal cord etc.
  • Battery operated device will have a drug reservoir and a miniature drive mechanism for delivering the drug through a catheter.
  • Refilling of drug can be achieved by injecting through a specific port.
  • The device will be powered by a battery which can be recharged by transcutaneous energy transfer system (TETS) thereby avoiding percutaneous wires and associated infections
Phase Principal Investigator:

Mr. Sarath S Nair

Principal Clinical Investigator:

-

Parylene Coating For Medical Devices And Delivery Systems

  • Parylene (poly paraxylylene) is a material used for coating medical devices and device delivery systems for imparting coatings with very low friction coefficient, good conformity and excellent dielectric properties.
  • The projects aims to develop the parylene coating on different substrates which can be further extended in the fabrication of medical devices such as Left Ventricular Assist Device (LVAD), Deep Brain Stimulator (DBS) etc and for the delivery system for Aortic Stent graft, Atrial Septal Defect Occluder, Flow Diverter Stent etc.
Phase Principal Investigator:

Dr. P. Ramesh

Principal Clinical Investigator:

-

Radiopaque Polymeric Microspheres For Embolization Therapy

  • Embolization involves the selective occlusion of blood vessels by purposely introducing emboli and is used to treat a wide variety of conditions affecting different organs of the human body like aneurysm, tumor isolation etc.
  • The objective of the project is to develop an indigenous technology for radiopaque polymeric microspheres intended for embolization therapy. The microspheres will contain covalently bound iodine as radiopacifying agent and polymer would be of non-degradable type
Phase Principal Investigator:

Dr. Roy Joseph

Principal Clinical Investigator:

Dr. Jayadevan E R