Cognition & Behavioral Neurology

PeopleServices Projects PublicationsResearch Staff

People
  • Ramshekhar N. Menon
    Neurologist
  • Aley Alexander
    Neuropsychologist
  • Sunita Justus
    Neuropsychologist
  • V. S. Lekha
    Medical Social Worker
  • P.S. Jairani
    Doctoral students
  • P. M. Aswathy
    Doctoral students
  • Sheela Nair
    Doctoral students
  • N. Ajisha
    Coordinator & Data Manager
Services

Being a tertiary referral centre for neurocognitive problems it caters to patients with amnesia, mild cognitive impairment, dementia, aphasia, neuropsychiatry syndromes and related conditions, arising as a primary disease or as a consequence of other diseases (like stroke), surgery, trauma or other causes are seen in this section. The section conducts a weekly Memory and Neurobehavioral (specialty) clinic.

Comprehensive diagnostic, medical management and counseling services are provided for these patients and their families.

Other Activities

Counseling and Care-giver support to patients with dementia is provided in collaboration with the Alzheimer's & Related Disorders Society of India, (ARDSI), Trivandrum Chapter.

The CBNS provides technical support and advice to the Alzheimer's & Related Disorders Society of India (ARDSI) for its Dementia day-care and full-time care facility 'Sneha Sadanam' in Trivandrum.

Active efforts with ARDSI to generate awareness amongst the medical community and educate the masses about dementia.

Publications
2009 onwards
  1. Mathuranath P S. The role of single photon emission computed tomography scan in the diagnosis of dementia. Neurology India 2010;58:823-4.
  2. P. M. Aswathy, P. S. Jairani, P. S. Mathuranath. Genetics of frontotemporal lobar degeneration. Annals of the Indian Academy of Neurology 2010;13:S55-S62.
  3. Pandurang R Wattamwar, P. S. Mathuranath. An overview of biomarkers in Alzheimer's disease. Annals of the Indian Academy of Neurology 2010;13:S116-23
  4. Neelima Ranjith, PS Mathuranath, Gangadhar Sharma, Aley Alexander. Qualitative aspects of learning, recall, and recognition in dementia. Annals of Indian Academy of Neurology 2010; 13:117-122.
  5. Mathuranath PS, Cherian PJ, Mathew R, Kumar S, George A, Alexander A, Ranjith N, Sarma PS. Dementia in Kerala, South India: prevalence and influence of age, education and gender. International Journal of Geriatric Psychiatry. 2010; 25: 290-297.
  6. Annamma George, Mathuranath PS. Progressive nonfluent aphasia in Malayalam: A case study. Indian Journal of Applied Linguistics. 2010,36:123-131.
2004-2008
  1. Mathew R, Mathuranath PS. Issues in evaluation of cognition in the elderly in developing countries (View Point). Annals of the Indian Academy of Neurology, 2008; 11 (2):82-88.
  2. Mathuranath PS, Cherian JP, Mathew R et al. Mini Mental State Examination and the Addenbrooke's Cognitive Examination: Effect of education and norms for a multicultural population. Neurology India. 2007;55:106-110
  3. Robert M, Mathuranath PS. Tau and tauopathies. Neurology India 2007;55(1):11-6.
  4. George A, Mathuranath PS. Community-based naming agreement, familiarity, image agreement and visual complexity ratings among adult Indians. Annals of Indian Academy of Neurology. 2007;10:92-99
  5. Mathuranath PS, George A, Mathew R, Cherian PJ. Profiles of language impairment in progressive nonfluent aphasia. Annals of Indian Academy of Neurology. 2006; 9(1): 25-31.
  6. Mathuranath P S, George A, Cherian P J, Mathew R, Sarma P S. Instrumental Activities Of Daily Living Scale For Dementia Screening in the elderly. International Psychogeriatrics 2005; 17(3):461-474.
  7. Annamma George, Mathuranath PS. Primary progressive aphasia: A comparative study of progressive nonfluent aphasia and semantic dementia. Neurology India 2005:53(2):162-165.
  8. Sureshkumar M, Mathuranath PS. Mild Cognitive Impairment. A Precussor of Dementia. A Review. Indian Journal of Clinical Psychology 2004;31(1);92-96.
  9. Mathuranath PS, Hodges JR, Mathew R, Cherian PJ, George A, Bak TH. Adaptation of the ACE for a Malayalam Speaking Population in Southern India. International Journal of Geriatric Psychiatry 2004;19:1-7.
1997-2003
  1. Mathuranath PS, George A, Cherian JP, Alexander A, Sarma SG, Sarma PS. Effects of Age, Education and Gender on Category and Letter Fluency. Journal of Clinical and Experimental Neuropsychology 2003; 25 (8): 1057-1064.
  2. Mathuranath PS, Xeureb JH, Bak T, Hodges JR. Corticobasal Ganglionic Degeneration and/or Frontotemporal Dementia? A Report of Two Overlap Cases and Review of Literature. Journal of Neurology Neurosurgery & Psychiatry 2000; 68: 304-312.
  3. Mathuranath PS, Nestor PJ, Berrios GE, Rakowicz W, Hodges JR. A brief cognitive test battery to differentiate Alzheimer's Disease and Frontotemporal Dementia. Neurology 2000;55:1613-1620.
  4. Mathuranath PS, Sarada C, Radhakrishnan KR. Paraneoplastic Neuromuscular Disorders: Evidence - Based Screening Approach For Systemic Cancers (Review). Annals of the Indian Academy of Neurology, 1998; 1 (1):10-17.
  5. Mathuranath PS, Pandian JD, Kishore A. Acute Pure Dysautonomia following Mumps (Case Report). Neurology India, 1999;47 (2):130-2.
  6. Mathuranath PS, Thomas SV. Hereditary Ataxias: From Phenotype to Genotype. (Review). Neurology India, 1998; 46: 5-14.
  7. Pandian JD, Mathuranath PS, Suresh PA, Radhakrishnan K. Myaesthenia Gravis, Motor Neurone Syndrome and Thymoma. (Case Report). Neurology India, 1998; 46 (3): 232-34.
  8. Pandian JD, Mathuranath PS. Beevor's sign in amyotrophic lateral sclerosis [Letter]. Neurology India, 1997; 45 (4): 283-84.
Research
In CBNS research is ongoing in the following areas.

Clinical Research: In the Indian population, profiling the symptomatology, evolution and longitudinal course of a) dementias including Alzheimer's disease (AD) and Fronto temporal lobar degenerations (FTLD); b) conditions with early cognitive deficits including Mild Cognitive Impariment (MCI) and Vascular Cognitive Impariment (VCI); c) estimating the dementia burden for the families; d) language deficits in primary progressive aphasias and stroke.

Epidemiological Research: A community based program of long-term longitudinal study of Cognition in Older Adults in Trivandrum (COAT) which is looking at changes in cognition associated with healthy aging, estimating incidence and prevalence of and risk factors (including dietary, gait social networking) and early markers, for mild cognitive impairment, Alzheimer's disease, and Vascular cognitive impairment in urban and rural elderly community dwellers.

Neurogenetics Research: The CBNS, in collaboration with the department of Biochemistry runs a Neurogenetics lab. Here population based genetic studies like estimation of prevalence of various ApoE allelic subtypes, and progranulin and tau gene related studes,

Biotechnology Research: Studies on estimation of serum levels of A-beta in patients with Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD), tau and progranulin levels in patients with Frontotemporal Dementia (FTD) are ongoing. Study of the role of macrophages in clearance of amyloid beta from brain in AD.

Neuroscience & Brain Mapping Research: The CBNC in collaboration with the department of Radiology runs a Brain Mapping lab. Here project on developing a Magnetic Resonance Imaging (MRI) template of Indian Brain, volumetric and voxel based morphometric (VBM) cross-sectional and longitudinal studies of various regions of interest in brains of patients with different dementia and neuropsychiatric diseases and functional MRI (fMRI) studies in some of these conditions are ongoing. Neuroscience fundamental research is being pursued in this lab in three areas- memory, language and vision, using behavioural experiments, fMRI and transcranial magnetic stimulation (TMS).

Neuropsychology & Tool Development Research: Translation and transcription of various neuropsychological instruments to suit the local population and standardization and deriving norms on them. There is also an ongoing project of developing a non-dominant hemisphere language assessment battery. The lab also has a University-Industry partnership collaborative project of developing and standardising a computerised neuropsychological battery for Indian population.