The effects of sleep manipulation on the various cognitive parameters including anxiety, emotions, learning and memory are studied employing various behavioral tests in animals. The effect of sleep restriction on spatial memory is tested using the radial arm maze (8 arms). Treatment induced anxiety is measured using elevated plus-maze, open field and light-dark chamber test. The different variables (e.g., total locomotion in the open field and closed-arm entries in the plus-maze, time spent in light and dark chamber etc) are analyzed using ANYMAZE software with videotracking system.
Neonatal anxiety testing: USV recorder
The effect of prenatal sleep deprivation on offspring is tested through recording their anxiety calls. The Ultrasonic vocalizations in neonates are used to quantify the emotional state in growing pups to study developmental plasticity. Ambulatory PSG and temperature monitoring in human
Wireless setup for sleep and multi-channel temperature recordings in human is soon coming up. The ambulatory PSG simultaneous with temperature monitoring from various sites of body are designed to understand interrelationship between sleep and body temperatures during normal and acute insomnia conditions. This would help in establishing the optimal ambient temperature required in eliciting and maintaining a good night's sleep. The study design translates into a potential non-pharmacological intervention in management of primary insomnia in different age groups. Services
Educational Activities: To organize workshops and conferences in area of Sleep
National Sleep Medicine workshop, NMSC2010 was conducted to provide introduction to basic sleep science, the technical and clinical aspects of sleep medicine. The program was organized for general practitioners, neurotechnicians and basic scientists in Kerala and southern India to bring awareness for Sleep Medicine and Research.
To organize Conferences on Sleep in order to generate wide-spread interest among Neuro-biologists and clinicians to take up research programmes to improve the basic knowledge of human sleep and sleep disorders in our country. These activities at national forum are aimed to promote Sleep Research, generate interdisciplinary teams to develop important diagnostic and effective therapeutic strategies at low cost for masses. Projects
Basic Research: To study neural dynamics in brain after sleep deprivation using animal models and simulation protocols in human. To identify the role of sleep during different phases of development in cognitive programming. To look for mechanism that interlinks sleep-body temperature in conditions of sleep restriction and scientific evaluation of Ayurvedic principles for regulation of sleep.
Translational Research: Evaluation of ambient temperature manipulation as a non-pharmacological intervention for treatment of primary insomnia and to find inflammatory markers after acute and chronic sleep deprivation.
To design, fabricate and evaluate prototype models of oral mandibular advancement device for the treatment of Obstructive Sleep Apnea. Publications
Gulia KK (2012). Dynamism in activity of the neural networks in brain is the basis of sleep-wakefulness oscillations. Front. Neurol. In press
Kumar VM (2010). Sleep is neither a passive nor an active phenomenon. Sleep Biol Rhythms. 8: 163-169.
Kumar VM (2008). Sleep and Sleep Disorders. Indian J Chest Dis Allied Sci. 50: 131-137.
Kumar VM, Vetrivelan R, Mallick HN (2007). Noradrenergic afferents and receptors in the medial preoptic area: neuroanatomical and neurochemical links between the regulation of sleep and body temperature. Neurochem Int. 50 :783-90. Staff
Prof. V Mohan Kumar, Visiting Professor, SCTIMST
Prof Jaya Kumari N (Biochemistry), SCTIMST
Dr Niranjan Kambatte (Instrumentation Lab), SCTIMST
Dr Roy Joseph (Polymer Processing Laboratory), SCTIMST
Dr Ashalatha Radhakrishnan (Neurology), SCTIMST