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BIOMEDICAL
TECHNOLOGY
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Bio
Ceramics Laboratory
This laboratory mainly concentrates on the
research and development of various bone
graft materials such as hydroxyapatite porous
granules, bioactive glass and their composites,
calcium phosphate cements etc. Research
is also on going in the areas of bioceramic-polymer
composites and biomimetic processing. The
laboratory is equipped with X-Ray Diffractometer,
Microhardness Tester etc.
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Scanning
Electron Microscope Facility
This facility has a Scanning Electron Microscope
attached with an Energy Dispersive X-Ray
Analysis (EDS) system with OXFORD Link Ultracool
Detector, having a resolution of 133eV/Mn.
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Biosurface
Technology Division
The basic activities of the laboratory are
to understand the blood/tissue material
interactions at the interface and develop
modified surfaces for various biomedical
applications such as haemoperfusion column,
bioprosthetic heart valve etc. Laboratory
is also interested in modifying interfaces
towards drug release studies including oral
insulin delivery system, artificial skin,
transdermal delivery systems and possible
peptide delivery system based on porous
hydroxyapatite microspheres.
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Polymer Division
The major activities of the laboratory are
development of implantable polymeric materials
for biomedical applications like high flex
life polyurethane - urea for heart valve
and cardiac pump, bioassimilable and injectable
unsaturated polyester bone cement for orthopaedic
applications, bioassimilable unsaturated
polyester-copolymer as blood-vessel barrier
to thrombosis etc.
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Laboratory for Polymer Analysis
The laboratory's activities are analytical
methods development, molecular imprinting,
cyclodextrins, modification of polymers,
development of super absorbing materials
for ophthalmic and other medical applications,
development of antibacterial polymers, metal
containing polymers and porous materials
for cell encapsulation or cell exclusion,
processes to impart antibacterial properties
and materials for guided tissue regeneration.
Analytical facilities include FTIR Spectroscopy,
Thermal Analysis, UV Spectroscopy etc.
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Division of Tissue Engineering and
Regeneration Technologies
Tissue engineering with a long term goal of
addressing the shortage of donor organs for
transplantation,by designing suitable organs
/ biological substitutes is a major thrust
area of this Division.The division has
ambitious research programmes to create
“organs” such as pancreas, cartilage,
blood vessels etc,that may be available
“off the shelf”’ and impact clinical
applications.Current major research programs
of the division have been directed to
develop (a) novel,biodegradable and bio
mimetic "designer" scaffolds (b)
understand the regeneration processes using
adult cells and directed stem cell
differentiation,and (c)delineate the
molecular pathways that regulates the growth
factors and other molecules or drugs to
promote regeneration.. Other areas of our
interest deal with usage of bioreactors,
wherein the “in vivo” environment is
recapitulated and monitored “in vitro,”
while exerting physiologically relevant
mechanical and biochemical stimuli to guide
neo tissue development. The division
also contributes to other lab and
institutional programs (e.g. lung, bone)
with “designer” scaffolds. Development
of biopolymer composites for medical
applications is another important area of
research. Scaffolds made by conventional
techniques and electro spinning as well as
regulator combinations generated by our
division, find additional applications in
drug delivery, wound healing and
haemostats.The division has been supported
with project grants from DST, DBT Govt of
India, and KSTEC, Kerala, been the Nodal
centre for the Joint Indo-US Centre for Stem
Cells & Tissue Engineering supported by
IUSSTF and is the Lead for the Centre
of Excellence in Tissue engineering program
with support from DBT, Govt of India.
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